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ea0049oc14.3 | Thyroid Cancer | ECE2017

TERT, BRAF and NRAS in the molecular profile of metastatic thyroid cancer: differences between primary and distant disease

Melo Miguel , Gaspar da Rocha Adriana , Batista Rui , Vinagre Joao , Joao Martins Maria , Costa Gracinda , Ribeiro Cristina , Carrilho Francisco , Leite Valeriano , Lobo Claudia , Manuel Cameselle-Teijeiro Jose , Sobrinho-Simoes Manuel , Soares Paula

Context: Little is known about the frequency of key mutations in thyroid cancer metastases and its relationship with the primary tumor genotype.Objectives: To evaluate the frequency of TERT promoter (TERTp), BRAF and NRAS mutations in metastatic thyroid carcinomas, analyzing primary thyroid tumors, lymph node metastases (LNM) and distant metastases.Material and Methods: Mutation analysis was performed in 437 tissue samples from 204...

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TERT, BRAF and NRAS in the molecular profile of metastatic thyroid cancer: differences between primary and distant disease

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